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                <text>The marine environment has proven to be a rich source of diverse natural products&#13;
with relevant activities such as anticancer, anti-inflammatory, antiepileptic, immunomodulatory,&#13;
antifungal, antiviral, and antiparasitic [1,2]. The global marine pharmaceutical&#13;
clinical pipeline comprises of 48 compounds originating from different marine invertebrates&#13;
and marine microorganisms, including 15 approved drugs by the most representative approving&#13;
agencies, 5 drug candidates in phase III, 12 in phase II, and 16 in phase I of drug&#13;
development clinical phases [3]. Marine invertebrates and associated microorganisms are&#13;
capable of synthesizing diverse classes of secondary metabolites and, in some cases, novel&#13;
chemical leads of which terrestrial counterparts have never been discovered.&#13;
The Red Sea is the world’s northernmost tropical sea, acting as an inlet of the Indian&#13;
Ocean, lying between Africa and Asia. It has a surface area of roughly 450,000 km2 and is&#13;
approximately 2250 km long, with a maximum depth of around 3000 m. The Red Sea is&#13;
approximately 5% greater than the world average salinity, due to a high rate of evaporation&#13;
and a lack of significant rivers or streams draining into it [4]. The Red Sea is a rich and&#13;
diverse ecosystem due to the 2000 km of coral reef extending along its coastline. It is&#13;
inhabited by over 1000 invertebrate species and 200 soft and hard corals [5]. Due to this&#13;
high biodiversity and limited research, the Red Sea is a promising, underexplored habitat&#13;
for the discovery of new bioactive marine natural products.&#13;
This Special Issue contains nine articles, including eight research articles on different&#13;
topics related to the natural products derived from the Red Sea and one review article. In&#13;
the following sections, we would provide a short overview of what the reader will find in&#13;
our Special Issue.&#13;
Qader et al. reported the isolation and identification of a new cyclic tripeptide named&#13;
epicotripeptin, along with four known cyclic dipeptides and one acetamide, derivative&#13;
from seagrass-associated endophytic fungus Epicoccum nigrum M13 recovered from the&#13;
Red Sea. Moreover, they reported two new compounds, cyclodidepsipeptide phragamide&#13;
A and trioxobutanamide derivative phragamide B, together with eight known compounds&#13;
from plant-derived endophyte Alternaria alternata 13A collected from a saline lake of the&#13;
Wadi El Natrun depression in the Sahara Desert. The antimicrobial screening indicated&#13;
that seven of the tested compounds exhibited considerable (MIC range of 2.5–5 μg/mL)&#13;
to moderate (10–20 μg/mL) antibacterial effect against the tested Gram-positive strains,&#13;
and moderate to weak (10–30 μg/mL) antibacterial effect against Gram-negative strains.&#13;
On the other hand, four of the tested compounds showed considerable antibiofilm effects&#13;
against biofilm-forming Gram-positive and Gram-negative strains [6].</text>
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Mostafa Rateb&#13;
Usama Ramadan Abdelmohsen</text>
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                <text>Jadik Wijayanto</text>
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Pedro López-RoldánSandra Fachelli</text>
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                <text>Marine environmental conditions are highly distinct in the Yellow Sea, the East China&#13;
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of the Yellow Sea, relatively warm subtropical conditions of the East China Sea, and&#13;
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In this Special Issue, we present a total of 12 articles covering a wide range of topics&#13;
for water column dynamics derived by the Kuroshio Current and various ecosystem&#13;
components in the Yellow Sea, the East China Sea, and the East/Japan Sea. A brief overview&#13;
of all the articles follows.</text>
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Sang Heon Lee&#13;
Seok-Hyun Youn</text>
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                <text>Jadik Wijayanto</text>
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