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                <text>The quality of drinking water is paramount for public health. Despite important improvements in the last decades, access to safe drinking water is not universal. The World Health Organization estimates that almost 10% of the population in the world do not have access to improved drinking water sources. Among other diseases, waterborne infections cause diarrhea, which kills nearly one million people every year, mostly children under 5 years of age. On the other hand, chemical pollution is a concern in high-income countries and an increasing problem in low- and middle-income countries. Exposure to chemicals in drinking water may lead to a range of chronic non-communicable diseases (e.g., cancer, cardiovascular disease), adverse reproductive outcomes, and effects on children’s health (e.g., neurodevelopment), among other health effects. Although drinking water quality is regulated and monitored in many countries, increasing knowledge leads to the need for reviewing standards and guidelines on a nearly permanent basis, both for regulated and newly identified contaminants. Drinking water standards are mostly based on animal toxicity data, and more robust epidemiologic studies with accurate exposure assessment are needed. The current risk assessment paradigm dealing mostly with one-by-one chemicals dismisses the potential synergisms or interactions from exposures to mixtures of contaminants, particularly at the low-exposure range. Thus, evidence is needed on exposure and health effects of mixtures of contaminants in drinking water. Finally, water stress and water quality problems are expected to increase in the coming years due to climate change and increasing water demand by population growth, and new evidence is needed to design appropriate adaptation policies.This Special Issue of International Journal of Environmental Research and Public Health (IJERPH) focuses on the current state of knowledge on the links between drinking water quality and human health.</text>
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                <text>The idea of combining drugs and diagnostics in oncology is not new. When the selective estrogen-receptor modulator tamoxifen was developed in the 1970s for the treatment of breast cancer, data&#13;
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                <text>Drug–drug interactions (DDIs) cause a drug to affect other drugs, leading to reduced drug
efficacy or increased toxicity of the affected drug. Some well-known interactions are
known to be the cause of adverse drug reactions (ADRs) that are life threatening to the
patient. Traditionally, DDI have been evaluated around the selective action of drugs on
specific CYP enzymes. The interaction of drugs with CYP remains very important in drug
interactions but, recently, other important mechanisms have also been studied as
contributing to drug interaction including transport- or UDP-glucuronyltransferase as a
Phase II reaction-mediated DDI. In addition, novel mechanisms of regulating DDIs can
also be suggested. In the case of the substance targeted for interaction, not only the DDIs
but also the herb–drug or food–drug interactions have been reported to be clinically
relevant in terms of adverse side effects. Reporting examples of drug interactions on a
marketed drug or studies on new mechanisms will be very helpful for preventing the side
effects of the patient taking these drugs. This Special Issue aims to highlight current
progress in understanding both the clinical and nonclinical interactions of commercial
drugs and the elucidation of the mechanisms of drug interactions.</text>
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                <text>Dong Hyun Kim
Sangkyu Lee
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St. Alban-Anlage 66
4052 Basel, Switzerland
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books@mdpi.com</text>
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                <text>ISBN 978-3-0365-2035-3 (Hbk)
ISBN 978-3-0365-2036-0 (PDF)</text>
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