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                <text>The cancer stem cell (CSC) paradigm represents one of the most prominent breakthroughs of the last decades in tumor biology. CSCs are that subpopulation within a tumor that can survive conventional therapies and as a consequence are able to fuel tumor recurrence. Nevertheless, the biological characteristics of CSCs and even their existence, remain the main topic among tumor biologists debates. The difficulty in achieving a better definition of CSC biology may actually be explained by the plasticity of such a cell subpopulation. Indeed, the emerging view is that CSCs represent a dynamic “state” of tumor cells that can acquire stemness-related properties under specific circumstances, rather than referring to a well-defined group of cells. Regardless of their origin, it is clear that designing novel antitumor treatments based on the eradication of CSCs will only be possible upon unraveling the biological mechanisms that underlie their pathogenic role in tumor progression and therapy resistance. The Special Issue on “New aspects of cancer stem cell biology: implications for innovative therapies” aims at highlighting recent insights into CSC features that can make them an attractive target for novel therapeutic strategies.&#13;
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Cadherin 11; WNT signaling; β-catenin; cancer stem cells; TNBC; early breast cancer; bevacizumab; neoadjuvant chemotherapy; ALDH1; solid cancer; chemo-resistance; HDAC inhibitors; head and neck squamous cell carcinoma; SRC; dasatinib; saracatinib; EC-8042; Ovarian cancer; Wnt signaling; tumor progression; therapy resistance; exosomes; oral cancer risk; oral epithelial dysplasia; SOX2; immunohistochemistry; oral squamous cell carcinoma; genome-wide; transcriptome; lung cancer; ATAC-seq; RNA-seq; CSCs; NSCLC; B4GALT1; LUAD; breast cancer; lipid; metabolism; therapeutic resistance; bowel cancer; organoid; tumoroid; colorectal; colon; stem cell; chemotherapy resistance; ovarian cancer; cancer stem cell; genetic heterogeneity; SNP array; L1CAM; chemoresistance; epithelial-mesenchymal transition; cancer therapy; cell adhesion molecule</text>
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                <text>Burrell, R.A.; Swanton, C. Tumour heterogeneity and the evolution of polyclonal drug resistance. Mol. Oncol.&#13;
2014, 8, 1095–1111. [CrossRef] [PubMed]</text>
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                <text>Colorectal surgery is one of the most performed procedures in dedicated colorectal and general surgery units worldwide. In the last two decades, the minimally invasive laparoscopic approach has become very popular worldwide, attracting great interest among patients (lower risk of infection, less pain, and faster recovery) and demonstrating excellent oncological results. Technology is improving rapidly, offering revolutionary innovations, particularly with the advent of robotic surgery, which offers important advantages over laparoscopy for both surgeons and patients: improved ergonomics, wristed instruments, and a better vision. These advantages may be particularly useful for more complex and challenging situations (complete mesocolic excision, low rectal cancer, one-stage treatment of colorectal and liver metastases, etc.), translating into potential improved surgical and oncological results. Although several books have been published on the subject, the great interest in robotic surgery makes it mandatory, in our opinion, to have a general update in view of the latest technical innovations and the results of the most relevant and recent literature. The book is divided into chapters dealing with the different colorectal segments with their robotic surgical operations and specific technical variants. The new frontiers of benign and emergency colorectal diseases are also considered, as well as the new robotic platforms recently introduced in the healthcare market. Some of them, such as the da Vinci SP single port device, may represent a revolutionary approach for this surgery. Training and cost aspects were also considered.</text>
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                <text>Criminology has until recently neglected the nature and levels of crime outside the urban realm. This is not a surprise as crime tends to concentrate in urban areas and the police directs resources where the problems are. Yet, there are many reasons why scholars, decision-makers and society as a whole should care about crime and safety in rural areas. This book highlights 20 reasons why crime and safety in rural areas is a topic of relevance. We attempt to untangle currently simplistic views of the rural by discussing a number of facets of the countryside as both safe and criminogenic, and more importantly, a hybrid place worth to be examined in its own right. We adopt the notion of a rural-urban continuum that captures the nuances of places of varied nature, spanning from remote and desolate spaces to accessible and connected environments of the urban fringe. Areas on the rural-urban continuum may be in constant transformation given local and global influences, which imposes challenges for policing and long-term social sustainability. Then, the book critically reviews a rich body of English-language literature in rural criminology that extends over more than four decades—a scholarship that has engaged researchers and practitioners in all continents. The books finishes with a discussion of the emergent research questions of the field, and offers implications for practice and the 2030 Sustainable Development Goals.</text>
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