86 10 3873 http://www.oer.unair.ac.id/files/original/21d81e31009cb8fec9d8aaa16efc7b3c.jpg 7dc94c1570e349c07ec4ccc65e285e2f http://www.oer.unair.ac.id/files/original/34c1f8ab89587728c72b328fdffd7c83.pdf 4edf898d1ce22ebbb253f22e8649c0ce Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource 610 Medicine and health Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Chapter 7 Vitamin C in Pneumonia and Sepsis Subject The topic of the resource Pharmacology Description An account of the resource In humans, ascorbic acid is an essential vitamin, anti-oxidant and co-factor of a variety of metal ion-dependent enzymatic reactions. In this review, the transport of L-ascorbic acid is described from food to target cells. Transport of ascorbic acid across the plasma membrane is facilitated by members of the SLC23 family, SLC23A1/SVCT1 and SLC23A2/SVCT2. We present in silico models of these transporters that provide new insights into the structure of the SLC23 family. While SVCT1 is mainly responsible for uptake of ascorbic acid from the intestine into the blood and for reabsorption in the kidney, the more broadly expressed transporter SVCT2 delivers ascorbic acid into tissues that are in high demand of the vitamin. The oxidized form of ascorbic acid, dehydroascorbic acid (DHA), is a substrate of the GLUT transporters belonging to the SLC2 family. They play important roles in ascorbic acid recycling, such as in the brain and in erythrocytes. Ascorbic acid serves as an essential co-factor of metal ion-dependent enzymes, keeping their metal ions in the reduced state. In addition, it serves as an effective antioxidant in cells with high metabolic activity such as neurons. Thus, it is not too surprising that changes in expression and function of the SVCTs have nutritional and pathological consequences such as during ageing, malnutrition and chronic alcohol abuse or in cancer, neurodegenerative diseases and chronic inflammation diseases. In the future, SVCT1 and SVCT2 may furthermore prove useful as drug delivery systems, to enhance transport of novel pharmaceutical agents more efficiently across the intestinal epithelium and the blood-cerebrospinal fluid barrier. Creator An entity primarily responsible for making the resource Carr, Anitra C. Source A related resource from which the described resource is derived Book Vitamin C URI https://library.oapen.org/handle/20.500.12657/40107 Publisher An entity responsible for making the resource available Publisher Taylor & Francis Publisher website https://taylorandfrancis.com/ Date A point or period of time associated with an event in the lifecycle of the resource 2020 Contributor An entity responsible for making contributions to the resource Tatik Rights Information about rights held in and over the resource https://creativecommons.org/licenses/by-nc-nd/4.0/ Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource English Type The nature or genre of the resource Textbook Identifier An unambiguous reference to the resource within a given context ISBN 9780429442025 Antioxidants ascorbic acid Infectious disease intravenous ascorbate OER OER Perpustakaan Universitas Airlangga Perpustakaan Unair pharmacology http://www.oer.unair.ac.id/files/original/34472e22311c790d5eb1dd2b20bae1f9.jpg cb1ef0abbfe35cfc126100a688c73dcc http://www.oer.unair.ac.id/files/original/82aa778a5670cbb7017a7d3f781f8786.pdf fed187197c313286e3ed110518f2ae82 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource 610 Medicine and health Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Chapter Assessing the Performance of Personal Protective Equipment1 Subject The topic of the resource Pharmacology Description An account of the resource Schistosomiasis is the second most prevalent parasitic disease in the world. Currently, the treatment of this disease relies on a single drug, praziquantel, and due to the identification of resistant parasites, the development of new drugs is urged. The demand for the development of robust high‐throughput parasite screening techniques is increasing as drug discovery research in schistosomiasis gains significance. Here, we review the most common methods used for compound screening in the parasites life stages and also summarize some of the methods that have been recently developed. In addition, we reviewed the methods most commonly implemented to search for promising targets and how they have been used to validate new targets against the parasite Schistosoma mansoni. We also review some promising targets in this parasite and show the main approaches and the major advances that have been achieved by those studies. Moreover, we share our experiences in schistosomiasis drug discovery attained with our S. mansoni drug screening platform establishment. Creator An entity primarily responsible for making the resource Kechagiadakis, Georgios Pirlot, Marc Source A related resource from which the described resource is derived https://library.oapen.org/handle/20.500.12657/49222 Publisher An entity responsible for making the resource available Publisher InTechOpen Publisher website https://www.intechopen.com/InTechOpen Date A point or period of time associated with an event in the lifecycle of the resource 2017 Contributor An entity responsible for making contributions to the resource Tatik Rights Information about rights held in and over the resource https://creativecommons.org/licenses/by/3.0/ Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource English Type The nature or genre of the resource Textbook Identifier An unambiguous reference to the resource within a given context DOI 10.5772/65778 drug screening histone‐modifying enzymes inhibitors OER OER Perpustakaan Universitas Airlangga Perpustakaan Unair protein kinases RNA interference Schistosoma mansoni http://www.oer.unair.ac.id/files/original/3165653ceef99c51a6bc3b544912a51e.jpg f78da25c6299ee53d77097a43ed586c5 http://www.oer.unair.ac.id/files/original/ea9e532cd329de1f69ba60a6ac594d12.pdf a9059aada57b47ffc0c4b8cba6f63ead http://www.oer.unair.ac.id/files/original/5be92e6b53862389125e15c97bdc6141.pdf a9059aada57b47ffc0c4b8cba6f63ead Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource 610 Medicine and health Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Chapter Bioreactor-Based Bone Tissue Engineering Subject The topic of the resource Pharmacology Description An account of the resource Omega-3 (ω-3) and omega-6 (ω-6) are polyunsaturated fatty acids (PUFAs) that play critical role in human health and have to be provided by food. In the brain, PUFAs are also precursors of endocannabinoids. The aim of this chapter is to review the existing literature on how dietary PUFAs impact on the endocannabinoid system in the brain and what are the consequences for brain function and dysfunction. In this chapter, we will first describe how PUFAs enter the brain, what are their metabolism processes and roles in brain function. We will describe the pathways from PUFAs to endocannabinoid production. Then, we will review the literature on how dietary ω-6/ω-3 ratio impacts the endocannabinoid system, in terms of endocannabinoid levels, proteins and endocannabinoid-dependent synaptic plasticity. In the next part, we will describe what we know about the interactions between PUFAs and endocannabinoids in neurological and neuropsychiatric disorders. Finally, we will conclude on the possible implications of the interactions between dietary PUFAs and endocannabinoids in the normal and pathological brain. In particular, we will discuss how dietary PUFAs, as homeostatic regulators of endocannabinoids, can constitute interesting therapeutic strategies for the prevention and/or treatment of neurological disorders with endocannabinoids impairment. Creator An entity primarily responsible for making the resource Marijanovic, Inga Antunovic, Maja Matic, Igor Panek, Marina Ivkovic, Alan Source A related resource from which the described resource is derived https://library.oapen.org/handle/20.500.12657/49147 Publisher An entity responsible for making the resource available Publisher InTechOpen Publisher website https://www.intechopen.com/ Date A point or period of time associated with an event in the lifecycle of the resource 2016 Contributor An entity responsible for making contributions to the resource Tatik Rights Information about rights held in and over the resource https://creativecommons.org/licenses/by/3.0/ Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource English Type The nature or genre of the resource Textbook Identifier An unambiguous reference to the resource within a given context DOI 10.5772/62546 brain endocannabinoids OER OER Perpustakaan Universitas Airlangga Omega-3 Perpustakaan Unair polyunsaturated fatty acid synaptic plasticity http://www.oer.unair.ac.id/files/original/2a9feb8bb9b3a98610cd3d3a179b91f9.jpg 1c33d46e13f5ffbdd2399ee730e10bef http://www.oer.unair.ac.id/files/original/883807d719c47350e075665ad6da0dca.pdf ac20865480ebfa47b16485a41c9aea4a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource 590 Animals (Zoology) Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Comportement, conduite et bien-être animal Subject The topic of the resource Animals Description An account of the resource This work outlines the general principles and recommendations on the raising of domestic animals applied to the Southern countries, especially tropical regions. These recommendations are important in a context of intensification of farms (dairy, poultry, etc.) and changes in conventional farming. They address the " Creator An entity primarily responsible for making the resource Manteca i Vilanova, Xavier Smith, Anthony J. Source A related resource from which the described resource is derived http://library.oapen.org/handle/20.500.12657/23940 Publisher An entity responsible for making the resource available éditions Quae Date A point or period of time associated with an event in the lifecycle of the resource 2014 Contributor An entity responsible for making contributions to the resource sawanah Rights Information about rights held in and over the resource https://creativecommons.org/licenses/by-nc-nd/2.0/ Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource French Type The nature or genre of the resource Textbook Identifier An unambiguous reference to the resource within a given context DOI 10.35690/978-2-7592-2243-8 http://www.oer.unair.ac.id/files/original/a822892582dc14844533ebc28c626290.jpg 0995f5edd4e70c690658256568037245 http://www.oer.unair.ac.id/files/original/7665a68bbe8ee8c7560e79c19d59b481.pdf ac20865480ebfa47b16485a41c9aea4a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource 590 Animals (Zoology) Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Cooperative Evolution Subject The topic of the resource Animals Description An account of the resource Cooperative Evolution offers a fresh account of evolution consistent with Charles Darwin's own account of a cooperative, inter-connected, buzzing and ever-changing world. Told in accessible language, treating evolutionary change as a cooperative enterprise brings some surprising shifts from the traditional emphasis on the dominance of competition. The book covers many evolutionary changes reconsidered as cooperation. These include the cooperative origins of life, evolution as a spiral rather than a ladder or tree, humans as a part of natural systems rather than the purpose, relationships between natural and social change, and the role of the individual in adaptive radiation onto new ground. The story concludes with a projection of human evolution from the past into the future. Creator An entity primarily responsible for making the resource Brown, Valerie A. Bryant, Christopher Source A related resource from which the described resource is derived https://library.oapen.org/handle/20.500.12657/48449 Publisher An entity responsible for making the resource available ANU Press Date A point or period of time associated with an event in the lifecycle of the resource 2021 Contributor An entity responsible for making contributions to the resource sawanah Rights Information about rights held in and over the resource https://creativecommons.org/licenses/by-nc-nd/4.0/ Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource English Type The nature or genre of the resource Textbook Identifier An unambiguous reference to the resource within a given context DOI 10.22459/CE.2021 ISBN 9781760464295, 9781760464295 http://www.oer.unair.ac.id/files/original/5aaa954d95b4304b3386904c64bcc848.jpg 602db3ec7193b1d1b268e7d19c922600 http://www.oer.unair.ac.id/files/original/56dc4571805e4f9b4a355312027ba585.pdf 6263bb19675ee85fbc6ba01b3bfa9ceb Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource 590 Animals (Zoology) Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Low-Dose Radiation Effects on Animals and Ecosystems Subject The topic of the resource Animals Description An account of the resource This open access book summarizes the latest scientific findings regarding the biological effects of the Fukushima Daiichi Nuclear Power Plant (FNPP) accident in 2011. Various cases of changes in animals and organisms have been reported since the FNPP accident. However, it is often unknown whether they are actually due to radiation, since the dose or dose-rate are not necessarily associated with the changes observed. This book brings together the works of radiation biologists and ecologists to provide reliable radioecology data and gives insight into future radioprotection. The book examines the environmental pollution and radiation exposure, and contains valuable data from abandoned livestock in the ex-evacuation zone and from wild animals including invertebrates and vertebrates, aqueous and terrestrial animals, and plants that are subjected to long-term exposure in the area still affected by radiation. It also analyzes dose evaluation, and offers new perspectives gained from the accident, as well as an overview for future studies to promote radioprotection of humans and the ecosystem. Since the biological impact of radiation is influenced by various factors, it is difficult to scientifically define the effects of low-dose/low-dose-rate radiation. However, the detailed research data presented can be combined with the latest scientific and technological advances, such as artificial intelligence, to provide new insights in the future. This book is a unique and valuable resource for researchers, professionals and anyone interested in the impact of exposure to radiation or contamination with radioactive materials. Creator An entity primarily responsible for making the resource Fukumoto, Manabu (editor) Source A related resource from which the described resource is derived http://library.oapen.org/handle/20.500.12657/23178 Publisher An entity responsible for making the resource available Springer Nature Date A point or period of time associated with an event in the lifecycle of the resource 2020 Contributor An entity responsible for making contributions to the resource sawanah Rights Information about rights held in and over the resource https://creativecommons.org/licenses/by/4.0 Format The file format, physical medium, or dimensions of the resource pdf Language A language of the resource English Type The nature or genre of the resource Textbooks Identifier An unambiguous reference to the resource within a given context DOI 10.1007/978-981-13-8218-5 http://www.oer.unair.ac.id/files/original/277ebfa2724a85b14f86dfdc4822e028.jpg 0bdd96a6b195abeaa27d02125b9bf139 http://www.oer.unair.ac.id/files/original/894f0b807164e678132cc22df9606c3f.pdf 66e7534fcb63f4ebd3d843a0aa8b28bc Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource 610 Medicine and health Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Chapter Challenges and New Frontiers in the Paediatric Drug Discovery and Development Subject The topic of the resource Pharmacology Description An account of the resource Drug discovery and development advances in the last decades allowed to find a treatment for many preventable diseases. However, all too often, children are excluded from these progresses since most of the new medicines have been discovered and developed for the adult population. Even if paediatricians routinely give drugs to children ‘off-label’, researchers have demonstrated that children do not respond to medications in the same way as adults. Furthermore, certain specific disorders are unique to children or occur in children differently than in adults. Besides specifically testing medicines in children in proper clinical studies taking into due account the peculiarity of this population, there is a growing recognition of the need to develop paediatric medicines having in mind the specificities of this vulnerable population. In this chapter, we will provide an overview on the drug discovery and development path for children highlighting challenges and new frontiers of each phase from the discovery to the preclinical and clinical development as well as we will provide a slightest hint about paediatric biomarkers discovery, age-appropriate formulation, pregnancy, and perinatal pharmacology and in silico pharmacology. Finally, pricing and reimbursement policies for medicines and new and existing research initiatives in the field will be discussed. URI https://library.oapen.org/handle/20.500.12657/49355 Keywords human development research, paediatric drug discovery, preclinical research, juvenile animal models, paediatric pharmacology, paediatric biomarkers, age-appropriate formulations, perinatal pharmacology, physiologically-based pharmacokinetic (PBPK) Creator An entity primarily responsible for making the resource Bonifazi, Donato Migliaccio, Giovanni Intini, Angelica Source A related resource from which the described resource is derived https://library.oapen.org/handle/20.500.12657/49355 Publisher An entity responsible for making the resource available Publisher InTechOpen Publisher website https://www.intechopen.com/ Date A point or period of time associated with an event in the lifecycle of the resource 2020 Contributor An entity responsible for making contributions to the resource Tatik Rights Information about rights held in and over the resource https://creativecommons.org/licenses/by/3.0/ Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource English Type The nature or genre of the resource Textbook Identifier An unambiguous reference to the resource within a given context DOI 10.5772/intechopen.85635 human development research OER OER Perpustakaan Universitas Airlangga paediatric drug discovery paediatric pharmacology perinatal pharmacology Perpustakaan Unair physiologically-based pharmacokinetic (PBPK) preclinical research http://www.oer.unair.ac.id/files/original/050ca1777b2bfa56e3713dc2179fe906.jpg f9491708147fff9d71d749d7c701d6e0 http://www.oer.unair.ac.id/files/original/3a6f8244d19d1172c2ade035b18ac870.pdf e8ad03e83c7cc08eed6704c920ca89d5 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource 610 Medicine and health Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultural Implications of the Fukushima Nuclear Accident Subject The topic of the resource Pharmaceutical industries Description An account of the resource Artificial Intelligence (incl. Robotics); Data Mining and Knowledge Discovery; Information Systems Applications (incl. Internet); User Interfaces and Human Computer Interaction; Pattern Recognition; Computer Communication Networks Creator An entity primarily responsible for making the resource Berthold, Michael R. Source A related resource from which the described resource is derived URI http://library.oapen.org/handle/20.500.12657/28129 Publisher An entity responsible for making the resource available Publisher Springer Nature Publisher website https://www.springernature.com/gp/products/books Date A point or period of time associated with an event in the lifecycle of the resource 2012 Contributor An entity responsible for making contributions to the resource Tatik Rights Information about rights held in and over the resource https://creativecommons.org/licenses/by-nc/4.0/ Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource English Type The nature or genre of the resource Textbook Identifier An unambiguous reference to the resource within a given context DOI 10.1007/978-3-642-31830-6 ISBN 9783642318290 Artificial Intelligence (incl. Robotics) Computer Communication Networks Data Mining and Knowledge Discovery Information Systems Applications (incl. Internet) OER OER Perpustakaan Universitas Airlangga Pattern Recognition Perpustakaan Unair User Interfaces and Human Computer Interaction http://www.oer.unair.ac.id/files/original/a1e08c2653f6270dce6f787f263251ab.jpg b3e2b4b0b713e6178397e6551453d465 http://www.oer.unair.ac.id/files/original/2d73e7f6c87cc143de184c6886e95ae6.pdf 112c4cc4cb9072c3d08eb652554de614 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource 510 Mathematics Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Quantization on Nilpotent Lie Groups Subject The topic of the resource Mathematical Description An account of the resource Topological Groups, Lie Groups; Abstract Harmonic Analysis; Functional Analysis; Mathematical Physics Creator An entity primarily responsible for making the resource Fischer, Veronique Ruzhansky, Michael Source A related resource from which the described resource is derived http://library.oapen.org/handle/20.500.12657/27971 Publisher An entity responsible for making the resource available Publisher Springer Nature Publisher website https://www.springernature.com/gp/products/books Date A point or period of time associated with an event in the lifecycle of the resource 2016 Contributor An entity responsible for making contributions to the resource Tatik Rights Information about rights held in and over the resource https://creativecommons.org/licenses/by/4.0/ Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource English Type The nature or genre of the resource Textbook Identifier An unambiguous reference to the resource within a given context DOI 10.1007/978-3-319-29558-9 ISBN 9789400775961 Functional Analysis Lie Groups Lie Groups; Abstract Harmonic Analysis Mathematical Physics OER OER Perpustakaan Universitas Airlangga Perpustakaan Unair Topological Groups http://www.oer.unair.ac.id/files/original/b939fecc0387c719a8e6179916be9aa1.jpg 3f055ce1f40dd242202d239ffb22fa4b http://www.oer.unair.ac.id/files/original/21476cfd0933df5f7f9a33f459f4fdf2.pdf 2f8ee7af7e5302e745392c73ab0104bb Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource 520 Astronomy Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Paris Climate Agreement: Beacon of Hope Subject The topic of the resource Pharmaceutical industries Description An account of the resource Climate Change; Climate Change Management and Policy; Energy Economics Creator An entity primarily responsible for making the resource Salawitch, Ross J. Canty, Timothy P. Hope, Austin P. Tribett, Walter R. Bennett, Brian F. Source A related resource from which the described resource is derived http://library.oapen.org/handle/20.500.12657/27732 Publisher An entity responsible for making the resource available Publisher Springer Nature Publisher website https://www.springernature.com/gp/products/books Date A point or period of time associated with an event in the lifecycle of the resource 2017 Contributor An entity responsible for making contributions to the resource Tatik Rights Information about rights held in and over the resource https://creativecommons.org/licenses/by/4.0/ Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource English Type The nature or genre of the resource Textbook Identifier An unambiguous reference to the resource within a given context DOI 10.1007/978-3-319-46939-3 ISBN 9783319730370 Climate Change Climate Change Management and Policy Energy Economics OER OER Perpustakaan Universitas Airlangga Perpustakaan Unair